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Therefore, contact your medical provider to evaluate your kidney health before starting this injection

The main difference is that tirzepatide tends to produce more significant appetite suppression due to its dual-receptor mechanism, so semaglutide users may find they can tolerate slightly larger portions

This may improve bioavailability and make therapy more accessible for patients who struggle with injections

We however think that GLP-1RAs should be avoided in people with HF with reduced ejection fraction until robust evidence of benefit is generated in this group